Perinatoloji Dergisi 2005; 1(1): 25-30

Online published date : 1 March 2005

Prenatal diagnoses with amniocentesis and cordocentesis: evaluation of 181 cases

 

Melih Atahan Güven*, Serdar Ceylaner**

 

* Kahramanmaraş Sütçüimam Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Kahramanmaraş, **Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Genetik Merkezi, Ankara

 

Aim: The aim of this study was to evaluate the results of invasive prenatal diagnostic procedures, amniocentesis and cordocentesis, performed in our clinic during 2002 and 2004.

Methods: Prenatal invasive diagnostic procedures were performed during 2002 and 2004 period of time due to high risk in triple screening test (? 1/270), advanced maternal age (? 35), anomaly detection during obstetric ultrasonography, and other indications were evaluated. Retrospectively, 150 cases (16-21 weeks), 31 cases (19-21 weeks) that were evaluated by amniocentesis and cordocentesis, respectively.

Results: Tissue cultures were successful in 150 of 153 cases (%98) evaluated by amniocentesis and %100 successful in all of 31 cordocentesis. Chromosomal abnormality rate was 3.8% (7/181) in all cases with successful cultures. The largest group of indications was high risk in triple screening test (78/ 181) in which the percentage of chromosomal abnormalities was 3.8% (3/78). There was no chromosomal abnormality detected in 49 (%27) cases with the indication of only advanced maternal age. In the evaluation of 23 (%12) cases with ultrasound abnormalities, 3 cases (13%) were detected with chromosomal abnormalities. Pregnant women presented with other indications (%18) in whom only one of 31 cases (3.2%) was chromosomal anomaly.

Conclusion: The rate of producing a successful tissue culture was %98 in our first retrospective study on fetal karyotype. There was no fetal loss in respect to the invasive procedure. Prenatal diagnosis must be performed in all cases with ultrasound abnormalities. Cases with low risk in triple screening test should be evaluated

 
Keywords

Amniocentesis, Cordocentesis, Fetal karyotype, Chromosomal abnormalities.