Objective: The aim of this study was to investigate the effect of fetal gender on first trimester Down syndrome screening markers.
Methods: 256 pregnancies in that fetal nuchal translucency and maternal serum free b-hCG and PAPP-A were evaluated and delivered in our clinics were included in the study. We investigated if these markers differed on the basis of fetal gender.
Results: Fetal nuchal translucency was measured 0.11 mm more in male fetuses than in female fetuses (P = 0.026). Although free b-hCG and PAPP-A levels were higher in female fetuses the difference was not statistically significant.Conclusion: The data of previous literature and the results of the present study suggest that first trimester markers differ on the basis of fetal gender, however it has no clinical meaning.